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Yes — acupuncture is generally well-tolerated alongside antidepressant medication, and a growing body of clinical research examines it specifically as an addition to medication. A 2025 review of 15 trials published in Frontiers in Neurology found that people who added acupuncture to their existing antidepressant treatment showed significantly greater improvement in depression scores — with measurable improvement appearing as early as the first week — and also reported fewer medication-related side effects. A 2022 review of 16 trials with nearly 2,000 participants published in the Journal of Integrative Medicine found similar results, including higher remission rates for the combined group. That said, we always recommend letting your prescribing provider know you're adding any new treatment, including acupuncture.